The use of ketotifen as long-term anti-inflammatory prophylaxis in children with PFAPA syndrome.

ABSTRACT:

Introduction

Periodic fever, aphthous stomatitis, pharyngitis and adenitis syndrome (PFAPA) is the most frequent periodic fever syndrome in children. Its pathogenesis is still unknown, but some disease-modifying factors were observed. Several medications were tested for the long-term prophylaxis of inflammatory flares; however, none are standardly used.

Methods

This prospective clinical trial enrolled 142 children (71 girls, 50%) meeting diagnostic criteria for PFAPA syndrome. We analysed selected clinical characteristics and compared laboratory parameters during the flare and attack-free period (at least two weeks after the attack). Moreover, we assessed the possible therapeutic effect of ketotifen on the duration of attack free-periods and clinical picture.

Results

SUBMITTER: Kapustova L 

PROVIDER: S-EPMC10748580 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature