Role of Kir4.1 Channels in Aminoglycoside-Induced Ototoxicity of Hair Cells.

ABSTRACT: The Kir4.1 channel, an inwardly rectifying potassium ion (K⁺) channel, is located in the hair cells of the organ of Corti as well as the intermediate cells of the stria vascularis. The Kir4.1 channel has a crucial role in the generation of endolymphatic potential and maintenance of the resting membrane potential. However, the role and functions of the Kir4.1 channel in the progenitor remain undescribed. To observe the role of Kir4.1 in the progenitor treated with the one-shot ototoxic drugs (kanamycin and furosemide), we set the proper condition in culturing Immortomouse-derived HEI-OC1 cells to express the potassium-related channels well. And also, that was reproduced in mice experiments to show the important role of Kir4.1 in the survival of hair cells after treating the ototo

SUBMITTER: Choi JS 

PROVIDER: S-EPMC10748730 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature