Genetics and Epigenetics in Obesity: What Do We Know so Far?

ABSTRACT:

Purpose of review

Enormous progress has been made in understanding the genetic architecture of obesity and the correlation of epigenetic marks with obesity and related traits. This review highlights current research and its challenges in genetics and epigenetics of obesity.

Recent findings

Recent progress in genetics of polygenic traits, particularly represented by genome-wide association studies, led to the discovery of hundreds of genetic variants associated with obesity, which allows constructing polygenic risk scores (PGS). In addition, epigenome-wide association studies helped identifying novel targets and methylation sites being important in the pathophysiology of obesity and which are essential for the generation of methylation risk scores (MRS). Despite their great p

SUBMITTER: Keller M 

PROVIDER: S-EPMC10748780 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature