The D ~ Sense ex-vivo viability assay application in a patient with stage IV lung adenocarcinoma: a case report.

ABSTRACT:

Background

The treatment resistance is a problem for lung cancer. In this study, we used a vitro tissue culturing system to select a new therapy strategy for a patient with tyrosine kinase inhibitors (TKIs) resistance.

Case presentation

A 42-year-old male Asian patient was diagnosed with advanced lung adenocarcinoma harboring an exon 19 deletion in the epidermal growth factor receptor (EGFR) gene. The patient was treated with Gefitinib, resulting in an almost complete remission for over a year. The patient relapsed after 13 months treatment, and received four cycles of chemotherapy. At 20 months, the patient had developed multiple lung metastases and a solitary cerebellar metastasis. An EGFR T790M mutation was identified in the peripheral blood sample. Subsequent treatment w

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC10748857 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature