Peptidomics insights: neutrophil extracellular traps (NETs) related to the chronic subdural hemorrhage.

ABSTRACT: Chronic subdural hemorrhage (CSDH) refers to a hematoma with an envelope between the dura mater and the arachnoid membrane and is more common among the elderly. It was reported that the dura mater, which is highly vascularized with capillary beds, precapillary arterioles and postcapillary venules play an important role in the protection of the central nervous system (CNS). Numerous evidences suggests that peptides play an important role in neuroprotection of CNS. However, whether dura mater derived endogenous peptides participate in the pathogenesis of CSDH remains undetermined. In the current study, the peptidomic profiles were performed in human dura of CSDH (three patients) and the relative control group (three non-CSDH samples) by LC-MS (liquid chromatography-mass spectrometry). The re

SUBMITTER: Li J 

PROVIDER: S-EPMC10749094 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature