Dysfunction of the glymphatic system in childhood absence epilepsy.

ABSTRACT:

Objective

This study aimed to evaluate the glymphatic system in childhood absence epilepsy (CAE) using diffusion tensor image analysis along the paravascular space (DTI-ALPS) index. Methods: Forty-two CAE patients and 50 age- and gender-matched healthy controls (HC) were included in this study. All participants underwent scanning using a Siemens 3.0 T magnetic resonance scanner, and the DTI-ALPS index was calculated. The study compared the differences of DTI-ALPS index between CAE patients and the healthy controls. Additionally, this study also assessed the relationship between the DTI-ALPS index and clinical characteristics such as age, seizure frequency, and duration of epilepsy.

Results

The DTI-ALPS index was lower in CAE patients compared to the healthy controls (1.45 ± 

SUBMITTER: Pu W 

PROVIDER: S-EPMC10749194 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature