Case report: Differential diagnosis of highly amplified anti-CD5 CAR T cells and relapsed lymphoma cells in a patient with refractory ALK positive anaplastic large cell lymphoma.

ABSTRACT:

Background

Anaplastic Large Cell Lymphoma (ALCL) is one of the most common subtypes of T-cell lymphoma. Among these, refractory and relapsed (r/r) ALK positive ALCL lacks effective therapies. The chimeric antigen receptor-modified T (CAR-T) cell therapy holds great promise as a therapeutic strategy for this disease. However, it is not known yet whether anti-CD5 CAR-T cells are sufficient for the definitive treatment of relapsed ALK⁺ ALCL, nor the role of accurate laboratory-based diagnoses during CAR-T treatment.

Case presentation

The adolescent patient received autologous T cells containing sequences encoding V_H domains specific to CD5. Following the infusion, there was an increase in both the copy number and proportion of CAR-T cells in peripheral blo

SUBMITTER: Mu W 

PROVIDER: S-EPMC10749197 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature