Metabolite profiling of Trichinella spiralis adult worms and muscle larvae identifies their excretory and secretory products.

ABSTRACT: Human trichinellosis is a parasitic infection caused by roundworms belonging to the genus Trichinella, especially Trichinella spiralis. Early and accurate clinical diagnoses of trichinellosis are required for efficacious prognosis and treatment. Current drug therapies are limited by antiparasitic resistance, poor absorption, and an inability to kill the encapsulating muscle-stage larvae. Therefore, reliable biomarkers and drug targets for novel diagnostic approaches and anthelmintic drugs are required. In this study, metabolite profiles of T. spiralis adult worms and muscle larvae were obtained using mass spectrometry-based metabolomics. In addition, metabolite-based biomarkers of T. spiralis excretory-secretory products and their related metabolic pathways were

SUBMITTER: Uthailak N 

PROVIDER: S-EPMC10749202 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature