Autophagy activation is required for N6-methyladenosine modification to regulate ferroptosis in hepatocellular carcinoma.

ABSTRACT:

Background & aims

Although ferroptosis holds promise as a new strategy for treating hepatocellular carcinoma (HCC), there are several obstacles that need to be overcome. One major challenge is the lack of understanding about the mechanisms underlying ferroptosis. Additionally, while the m⁶A modification has been shown to regulate various forms of cell death, its role in regulating ferroptosis in HCC has been largely overlooked. Bridging this knowledge gap, our study aimed to elucidate the regulatory influence of m⁶A modification on HCC ferroptosis.

Materials

Dot blot and EpiQuik m⁶A RNA Methylation Quantitative kit detected changes in overall m⁶A modification level during ferroptosis in HCC. MeRIP-qPCR and RIP-qPCR identified that

SUBMITTER: Li Y 

PROVIDER: S-EPMC10749285 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature