Trogocytosis of CAR molecule regulates CAR-T cell dysfunction and tumor antigen escape.

ABSTRACT: Chimeric antigen receptor (CAR) T-cell therapy has demonstrated clinical response in treating both hematologic malignancies and solid tumors. Although instances of rapid tumor remissions have been observed in animal models and clinical trials, tumor relapses occur with multiple therapeutic resistance mechanisms. Furthermore, while the mechanisms underlying the long-term therapeutic resistance are well-known, short-term adaptation remains less understood. However, more views shed light on short-term adaptation and hold that it provides an opportunity window for long-term resistance. In this study, we explore a previously unreported mechanism in which tumor cells employ trogocytosis to acquire CAR molecules from CAR-T cells, a reversal of previously documented processes. This mechanism resul

SUBMITTER: Zhai Y 

PROVIDER: S-EPMC10749292 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature