Nutritional management of a dog with hepatic enzymopathy suspected to be secondary to copper-associated hepatitis: a case report.

ABSTRACT: A 4-year-old, female-spayed American Bulldog presented to the Ontario Veterinary College's Health Sciences Center's Clinical Nutrition Service for nutritional management of hepatic enzymopathy and suspected copper-associated hepatitis. Medical history revealed a 3-month history of gradually increasing serum ALT. Additional diagnostics included negative Leptospira titters, normal bile acids, and laparoscopic liver biopsy. Histopathology findings were consistent with diffuse moderate vacuole hepatocellular degeneration, mild positive copper staining, mild chronic lymphoplasmacytic hepatitis both portal and central, and mild biliary hyperplasia. Hepatic copper quantification results were above normal ranges (630 μg/g dry tissue), but below those seen in familial copper-associated hepat

SUBMITTER: Poblanno Silva FM 

PROVIDER: S-EPMC10749294 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature