Large-scale genome-wide association study to identify causal relationships and potential mediators between education and autoimmune diseases.

ABSTRACT:

Objectives

Epidemiological studies suggested a potential connection between education and autoimmune disorders. This study investigated the possible cause-and-effect relationship using a Mendelian randomization approach.

Methods

We explored the causality between four education traits (n = 257,841~1,131,881) and 22 autoimmune diseases. The mediating role of smoking (632,802 individuals), BMI (681,275 individuals), alcohol (335,394 individuals), and income (397,751 individuals) was also investigated. Transcriptome-wide association study (TWAS) and enriched signaling pathways analysis were used to investigate the underlying biological mechanisms.

Results

Especially, higher cognitive performance was protective for psoriasis (odds ratio (OR) = 0.69, 95% confidence interval

SUBMITTER: Li Y 

PROVIDER: S-EPMC10749315 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature