Risk factors for the rupture of intracranial aneurysms: a systematic review and meta-analysis.

ABSTRACT:

Purpose

The study aimed to identify potential risk factors for aneurysm rupture by performing a systematic review and meta-analysis.

Materials and methods

We systematically searched the PubMed, Embase, and Cochrane Library electronic databases for eligible studies from their inception until June 2023.

Results

Eighteen studies involving 17,069 patients with unruptured intracranial aneurysm (UIA) and 2,699 aneurysm ruptures were selected for the meta-analysis. Hyperlipidemia [odds ratio (OR): 0.47; 95% confidence interval (CI): 0.39-0.56; p < 0.001] and a family history of subarachnoid hemorrhage (SAH) (OR: 0.81; 95% CI: 0.71-0.91; p = 0.001) were associated with a reduced risk of aneurysm rupture. In contrast, a large-size aneurysm (OR: 4.49; 95% CI: 2.46

SUBMITTER: Ma J 

PROVIDER: S-EPMC10749344 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature