Dysfunction of the aging female mouse urethra is associated with striated muscle loss and increased fibrosis: an initial report.

ABSTRACT: The decline of urethral function with advancing age plays a major role in urinary incontinence in women, impairing quality of life and economically burdening the health care system. However, none of the current urinary incontinence treatments address the declining urethral function with aging, and the mechanisms by which aging impacts urethra physiology remain little known or explored. Here, we have compared functional, morphometric, and global gene expression of urethral tissues between young and old female mice. Bladder leak point pressure (LPP) measurement showed that the aged female mice had 26.55% lower LPP compared to younger mice. Vectorized Scale-Invariant Pattern Recognition (VIPR) analysis of the relative abundance of different tissue components revealed that the mid-urethra of o

SUBMITTER: Sadeghi Z 

PROVIDER: S-EPMC10749384 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature