Vitamin D Receptor Gene Polymorphisms and Association with Vitiligo in Indonesian Population.

ABSTRACT:

Introduction

Vitiligo is an acquired depigmenting skin disorder due to the loss of melanocyte function in the epidermis and hair follicles. The pathogenesis of vitiligo is multifactorial, with genetics being a predisposing factor. Previous studies had varying results regarding whether or not polymorphisms of vitamin D receptor (VDR) gene are associated with the risk of vitiligo in specific populations. This study investigated the association between three frequently analyzed VDR gene polymorphisms (ApaI, BsmI, TaqI) and susceptibility to vitiligo in Indonesian population.

Methods

Thirty-four vitiligo patients and 34 age- and sex-matched healthy subjects aged ≥18 years old were recruited in the Dermatology and Venereology Outpatient Clinic of Dr. Hasan Sa

SUBMITTER: Maharani RH 

PROVIDER: S-EPMC10749542 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature