Rewiring cancer drivers to activate apoptosis.

ABSTRACT: Genes that drive the proliferation, survival, invasion and metastasis of malignant cells have been identified for many human cancers^1-4. Independent studies have identified cell death pathways that eliminate cells for the good of the organism^5,6. The coexistence of cell death pathways with driver mutations suggests that the cancer driver could be rewired to activate cell death using chemical inducers of proximity (CIPs). Here we describe a new class of molecules called transcriptional/epigenetic CIPs (TCIPs) that recruit the endogenous cancer driver, or a downstream transcription factor, to the promoters of cell death genes, thereby activating their expression. We focused on diffuse large B cell lymphoma, in which the transcription factor B cell lymphoma 6 (BCL6) is d

SUBMITTER: Gourisankar S 

PROVIDER: S-EPMC10749586 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature