Endorepellin downregulation promotes angiogenesis after experimental traumatic brain injury.

ABSTRACT: Endorepellin plays a key role in the regulation of angiogenesis, but its effects on angiogenesis after traumatic brain injury are unclear. This study explored the effects of endorepellin on angiogenesis and neurobehavioral outcomes after traumatic brain injury in mice. Mice were randomly divided into four groups: sham, controlled cortical impact only, adeno-associated virus (AAV)-green fluorescent protein, and AAV-shEndorepellin-green fluorescent protein groups. In the controlled cortical impact model, the transduction of AAV-shEndorepellin-green fluorescent protein downregulated endorepellin while increasing the number of CD31⁺/Ki-67⁺ proliferating endothelial cells and the functional microvessel density in mouse brain. These changes resulted in improved neurological

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC10749628 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature