Long-term Use of Ibrutinib in Japanese Patients with Steroid Dependent/Refractory cGVHD: Final Analysis of Multicenter Study.

ABSTRACT:

Background

Chronic graft-versus-host disease (cGVHD) is a serious complication after allogeneic stem cell transplantation. Poor prognosis has been shown in patients with cGVHD after the failure of primary steroid-based treatments. A previous report demonstrated the efficacy and safety of ibrutinib in these patients, leading to the approval of ibrutinib for cGVHD in Japan. Here, we report the extended follow-up of patients in this study.

Objectives

To evaluate the safety and efficacy of ibrutinib in Japanese patients with steroid-dependent or refractory cGVHD.

Study design

An open-label, single-arm, multicenter study of ibrutinib in Japanese patients with steroid-dependent or refractory cGVHD (NCT No.: NCT03474679; Clinical Registry No.: CR108443).

Results

At th

SUBMITTER: Toyosaki M 

PROVIDER: S-EPMC10749732 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature