Cancer risk in the siblings of individuals with major birth defects: a large Nordic population-based case-control study.

ABSTRACT:

Background

Individuals with major birth defects are at increased risk of developing cancer, indicating a common aetiology. However, whether the siblings of individuals with birth defects are also at an increased risk of cancer is unclear.

Methods

We used nationwide health registries in four Nordic countries and conducted a nested case-control study. We included 40 538 cancer cases (aged 0-46 years) and 481 945 population controls (matched by birth year and country), born between 1967 and 2014. The relative risk of cancer among individuals whose siblings had birth defects was computed with odds ratios (OR) and 95% confidence intervals (CIs), using logistic regression models.

Results

In the total study population (aged 0-46 years), we observed no overall difference in c

SUBMITTER: Daltveit DS 

PROVIDER: S-EPMC10749741 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature