Alcohol intake including wine drinking is associated with decreased platelet reactivity in a large population sample.

ABSTRACT:

Background

Alcohol consumption is linked to decreased platelet function. Whether this link is dependent on sex or type of beverage remains unclear.

Methods

Cross-sectional data were obtained from the Framingham Heart Study (N = 3427). Alcohol consumption was assessed by using standardized medical history and Harvard semi-quantitative food frequency questionnaires. Five bioassays measured 120 platelet reactivity traits across agonists in whole-blood and platelet-rich plasma samples. Linear mixed-effects models adjusted for age, sex and aspirin use, hypertension, body mass index, cholesterol, high-density lipoprotein, triglycerides, smoking and diabetes evaluated associations between platelet reactivity and alcohol consumption. Beta effects, the regression coefficients that es

SUBMITTER: Pashek RE 

PROVIDER: S-EPMC10749750 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature