Mediation and moderation of genetic risk of obesity through eating behaviours in two UK cohorts.

ABSTRACT:

Background

The mechanisms underlying genetic predisposition to higher body mass index (BMI) remain unclear.

Methods

We hypothesized that the relationship between BMI-genetic risk score (BMI-GRS) and BMI was mediated via disinhibition, emotional eating and hunger, and moderated by flexible (but not rigid) restraint within two UK cohorts: the Genetics of Appetite Study (GATE) (n = 2101, 2010-16) and the Avon Longitudinal Study of Parents and Children (ALSPAC) (n = 1679, 2014-18). Eating behaviour was measured by the Adult Eating Behaviour Questionnaire and Three-Factor Eating Questionaire-51.

Results

The association between BMI-GRS and BMI were partially mediated by habitual, emotional and situational disinhibition in the GATE/ALSPAC meta-mediation [standardized betaind

SUBMITTER: Begum S 

PROVIDER: S-EPMC10749755 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature