Trajectories of kidney function and risk of mortality.

ABSTRACT:

Background

We aimed to identify patterns within the rate of kidney function decline, determinants of these patterns and their association with all-cause mortality risk in the general population.

Methods

Participants aged ≥ 45 years with at least one assessment of creatinine-based estimated glomerular filtration rate (eGFR) taken between 1997 and 2018 were selected from a population-based cohort study. Analyses were performed using several distinct latent class trajectory modelling methods. Cumulative incidences were calculated with 45 years of age as the starting point.

Results

In 12 062 participants (85 922 eGFR assessments, mean age 67.0 years, 58.7% women, median follow-up 9.6 years), four trajectories of eGFR change with age were identified: slow eGFR decline [rat

SUBMITTER: van der Burgh AC 

PROVIDER: S-EPMC10749765 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature