Independent relevance of adiposity measures to coronary heart disease risk among 0.5 million adults in UK Biobank.

ABSTRACT:

Background

Evidence on body fat distribution shows opposing effects of waist circumference (WC) and hip circumference (HC) for coronary heart disease (CHD). We aimed to investigate the causality and the shape of such associations.

Methods

UK Biobank is a prospective cohort study of 0.5 million adults aged 40-69 years recruited between 2006 and 2010. Adjusted hazard ratios (HRs) for the associations of measured and genetically predicted body mass index (BMI), WC, HC and waist-to-hip ratio with incident CHD were obtained from Cox models. Mendelian randomization (MR) was used to assess causality. The analysis included 456 495 participants (26 225 first-ever CHD events) without prior CHD.

Results

All measures of adiposity demonstrated strong, positive and approximately lo

SUBMITTER: Trichia E 

PROVIDER: S-EPMC10749766 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature