Adiposity and risk of oesophageal cancer subtypes in the Million Women Study.

ABSTRACT:

Background

The strong association of body mass index (BMI) with increased oesophageal adenocarcinoma risk is established, but its relationship with oesophageal squamous cell carcinoma is less clear. There is little evidence regarding the association of abdominal adiposity with either subtype.

Methods

In a large prospective cohort of women in the UK, mean age 56.2 [standard deviation (SD) = 4.9] years, we investigated the risk of oesophageal adenocarcinoma and squamous cell carcinoma in relation to self-reported BMI, waist circumference (WC) and waist-hip ratio (WHR), using Cox regression to estimate adjusted relative risks (RR) and 95% confidence intervals (CIs), taking account of potential reverse causation bias.

Results

During mean follow-up of 17.7 (SD = 4.9) years

SUBMITTER: Sweetland S 

PROVIDER: S-EPMC10749780 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature