AMGDTI: drug-target interaction prediction based on adaptive meta-graph learning in heterogeneous network.

ABSTRACT: Prediction of drug-target interactions (DTIs) is essential in medicine field, since it benefits the identification of molecular structures potentially interacting with drugs and facilitates the discovery and reposition of drugs. Recently, much attention has been attracted to network representation learning to learn rich information from heterogeneous data. Although network representation learning algorithms have achieved success in predicting DTI, several manually designed meta-graphs limit the capability of extracting complex semantic information. To address the problem, we introduce an adaptive meta-graph-based method, termed AMGDTI, for DTI prediction. In the proposed AMGDTI, the semantic information is automatically aggregated from a heterogeneous network by training an adaptive meta-g

SUBMITTER: Su Y 

PROVIDER: S-EPMC10749791 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature