Dataset Information

Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study.

ABSTRACT:

Background

Altered autonomic modulation, measured by heart rate variability (HRV), has been found to be associated with dementia risk in the elderly. However, long-term follow-up study evaluating the association between autonomic modulation from middle-age and the incidence of dementia has been limited.

Methods

This retrospective cohort analyzed data from Taiwan's National Health Insurance Database covering the period from 2001 to 2017, with a linkage to citywide health examinations conducted by Tainan Metropolitan City, Taiwan. We included subjects aged 45-64 years. The mean follow-up period was 15.75 ± 3.40 years. The measurements of HRV included resting heart rate, high frequency (HF), low frequency (LF), standard deviation of normal-to-normal R-R intervals (SDNN), ratio between the 30th and 15th R-R interval after standing up from the supine position (30/15 ratio), ratio between the R-R intervals during expiration and inspiration, and the ratio between the high- and low-frequency components (LF/HF). The main study outcome was the incidence of dementia. We performed multivariable Cox proportional hazard regression models to compare the risk of dementia among different HRV subgroups.

Results

We included 565 participants with a mean age of 53 (SD: 6) years, of whom 44% were male. The risk of dementia was significantly increased in association with lower parasympathetic HRV modulation, including SDNN (HR: 3.23, 95% CI: 1.55-6.73) and 30/15 ratio (HR: 3.52, 95%CI: 1.67-7.42). Moreover, the risk of dementia was increased in subjects with higher LF/HF ratios (HR: 2.05, 95% CI: 1.12-3.72).

Conclusions

Lower parasympathetic activity and higher sympathetic-vagal imbalance in middle-age were associated with dementia risk.

SUBMITTER: Chou YT

PROVIDER: S-EPMC10749883 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature

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Publications

Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study.

Chou Yu-Tsung YT Sun Zih-Jie ZJ Shao Shih-Chieh SC Yang Yi-Ching YC Lu Feng-Hwa FH Chang Chih-Jen CJ Liao Tzu-Chi TC Li Chung-Yi CY Chen Tony Hsiu-Hsi TH Wu Jin-Shang JS Lai Edward Chia-Cheng EC

Biomedical journal 20221226 6

<h4>Background</h4>Altered autonomic modulation, measured by heart rate variability (HRV), has been found to be associated with dementia risk in the elderly. However, long-term follow-up study evaluating the association between autonomic modulation from middle-age and the incidence of dementia has been limited.<h4>Methods</h4>This retrospective cohort analyzed data from Taiwan's National Health Insurance Database covering the period from 2001 to 2017, with a linkage to citywide health examinatio ...[more]

PMID: 36581249

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Dataset Information

Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study.

Background

Methods

Results

Conclusions

Publications

Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study.

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