Autonomic modulation and the risk of dementia in a middle-aged cohort: A 17-year follow-up study.

ABSTRACT:

Background

Altered autonomic modulation, measured by heart rate variability (HRV), has been found to be associated with dementia risk in the elderly. However, long-term follow-up study evaluating the association between autonomic modulation from middle-age and the incidence of dementia has been limited.

Methods

This retrospective cohort analyzed data from Taiwan's National Health Insurance Database covering the period from 2001 to 2017, with a linkage to citywide health examinations conducted by Tainan Metropolitan City, Taiwan. We included subjects aged 45-64 years. The mean follow-up period was 15.75 ± 3.40 years. The measurements of HRV included resting heart rate, high frequency (HF), low frequency (LF), standard deviation of normal-to-normal R-R intervals (SDNN), ratio

SUBMITTER: Chou YT 

PROVIDER: S-EPMC10749883 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature