Pharmacological activation of constitutive androstane receptor induces female-specific modulation of hepatic metabolism.

ABSTRACT:

Background & aims

The constitutive androstane receptor (CAR) is a nuclear receptor that binds diverse xenobiotics and whose activation leads to the modulation of the expression of target genes involved in xenobiotic detoxification and energy metabolism. Although CAR hepatic activity is considered to be higher in women than in men, its sex-dependent response to an acute pharmacological activation has seldom been investigated.

Methods

The hepatic transcriptome, plasma markers, and hepatic metabolome, were analysed in Car^+/+ and Car^-/- male and female mice treated either with the CAR-specific agonist 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) or with vehicle.

Results

Although 90% of TCPOBOP-sensitive genes were modulated in a

SUBMITTER: Huillet M 

PROVIDER: S-EPMC10749885 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature