Gut microbiota composition is associated with disease severity and host immune responses in COVID-19.

ABSTRACT:

Background

Human gut microbiota play a crucial role in the immune response of the host to respiratory viral infection. However, evidence regarding the association between the gut microbiome, host immune responses, and disease severity in coronavirus disease 2019 (COVID-19) remains insufficient.

Methods

To better comprehend the interactions between the host and gut microbiota in COVID-19, we conducted 16S rRNA sequencing and characterized the gut microbiome compositions in stool samples from 40 COVID-19 patients and 33 non-pneumonia controls. We assessed several hematological parameters to determine the immune status.

Results

We found that the gut microbial composition was significantly changed in COVID-19 patients, which was characterized by increased opportunistic pa

SUBMITTER: Fan R 

PROVIDER: S-EPMC10749918 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature