Excessive daytime sleepiness is associated with impaired antibody response to influenza vaccination in older male adults.

ABSTRACT:

Background

The reduced effectiveness of standard-dose influenza vaccines in persons ≥65 years of age led to the preferential recommendation to use high-dose (HDFlu) or MF59-adjuvanted (MF59Flu) vaccines for this age group. Sleep is an important modulator of immune responses to vaccines and poor sleep health is common in older adults. However, potential effects of poor sleep health on immune responses to influenza vaccination in older adults remain largely unknown.

Methods

We conducted a cohort study of 210 healthy participants age ≥65 years, who received either seasonal high-dose (HDFlu) or MF59-adjuvanted (MF59Flu) influenza vaccine. We assessed sleep characteristics in this cohort by standardized questionnaires and measured the antibody titer against influenza A/H3N2 virus

SUBMITTER: Quach HQ 

PROVIDER: S-EPMC10749933 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature