Hepatitis C Cascade of Care in the Direct-Acting Antivirals Era: A Meta-Analysis.

ABSTRACT:

Introduction

The hepatitis C virus (HCV) epidemic remains a public health problem worldwide. A systematic review and meta-analysis were conducted to provide evidence of outcomes attained across the HCV care cascade in the era of direct-acting antivirals.

Methods

Studies from North America, Europe, and Australia (January 2014 through March 2021) reporting on HCV care cascade outcomes (screening to cure) were included. When calculating the proportions of individuals completing each step, the numerator for Steps 1-8 was the number of individuals completing each step; the denominator was the number of individuals completing the previous step for Steps 1-3 and Step 3 for Steps 4-8. In 2022, random effects meta-analyses were conducted to estimate pooled proportions with 95% CIs.

SUBMITTER: Hernandez-Con P 

PROVIDER: S-EPMC10749988 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature