CD248 promotes insulin resistance by binding to the insulin receptor and dampening its insulin-induced autophosphorylation.

ABSTRACT:

Background

In spite of new treatments, the incidence of type 2 diabetes (T2D) and its morbidities continue to rise. The key feature of T2D is resistance of adipose tissue and other organs to insulin. Approaches to overcome insulin resistance are limited due to a poor understanding of the mechanisms and inaccessibility of drugs to relevant intracellular targets. We previously showed in mice and humans that CD248, a pre/adipocyte cell surface glycoprotein, acts as an adipose tissue sensor that mediates the transition from healthy to unhealthy adipose, thus promoting insulin resistance.

Methods

Molecular mechanisms by which CD248 regulates insulin signaling were explored using in vivo insulin clamp studies and biochemical analyses of cells/tissues from CD248 knockout (KO) and w

SUBMITTER: Benedet PO 

PROVIDER: S-EPMC10750038 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature