General joint hypermobility in temporomandibular joint disease; clinical characteristics, biomarkers, and surgical aspects.

ABSTRACT:

Objectives

This study aimed at identifying biomarkers in the temporomandibular joint (TMJ) synovial tissue analysing 28 extra cellular matrix proteins in TMJ diseased patients, classified with either general joint hypermobility (GJH) or normal joint mobility (NJM), and to compile clinical and protein characterisation to reveal potential surgical predictive factors.

Study design

A prospective observational cohort study including 97 consecutive patients scheduled for TMJ surgery was performed. Joint mobility and several other predefined clinical variables were recorded. Synovial tissue was harvested during surgery followed by examination using multi-analytic profiling. A multivariate quantile regression model was used for analysis purposes.

Results

The GJH/NJM ratio was

SUBMITTER: Ulmner M 

PROVIDER: S-EPMC10750043 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature