Immunomodulatory role of vasoactive intestinal peptide and ghrelin in Oncorhynchus mykiss.

ABSTRACT: Neuropeptides are a group of peptides derived from precursor proteins synthesized in neuronal and nonneuronal cells. The classical functions of neuropeptides have been extensively studied in mammals, including neuromodulation in the central nervous system, molecular signaling in the peripheral nervous system, and immunomodulation associated mainly with anti-inflammatory activity. In contrast, in teleosts, studies of the immunomodulatory function of these neuropeptides are limited. In Oncorhynchus mykiss, vasoactive intestinal peptide (VIP) mRNA sequences have not been cloned, and the role of VIP in modulating the immune system has not been studied. Furthermore, in relation to other neuropeptides with possible immunomodulatory function, such as ghrelin, there are also few studies. Th

SUBMITTER: Munoz-Flores C 

PROVIDER: S-EPMC10750074 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature