Multitissue Circadian Proteome Atlas of WT and Per1^-/-/Per2^-/- Mice.

ABSTRACT: The molecular basis of circadian rhythm, driven by core clock genes such as Per1/2, has been investigated on the transcriptome level, but not comprehensively on the proteome level. Here we quantified over 11,000 proteins expressed in eight types of tissues over 46 h with an interval of 2 h, using WT and Per1/Per2 double knockout mouse models. The multitissue circadian proteome landscape of WT mice shows tissue-specific patterns and reflects circadian anticipatory phenomena, which are less obvious on the transcript level. In most peripheral tissues of double knockout mice, reduced protein cyclers are identified when compared with those in WT mice. In addition, PER1/2 contributes to controlling the anticipation of the circadian rhythm, modulating tissue-specific cyclers as well as key pathwa

SUBMITTER: Qian L 

PROVIDER: S-EPMC10750102 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature