Dexmedetomidine During Therapeutic Hypothermia: A Multicenter Quality Initiative.

ABSTRACT:

Objectives

Sedation is typically used during neonatal therapeutic hypothermia (TH). This report describes a quality improvement (QI) initiative with the aim of decreasing opioid exposure during TH by implementing dexmedetomidine as the primary sedative agent.

Methods

This dual-center QI initiative used a multidisciplinary team to create a sedation algorithm for safe implementation of dexmedetomidine as first-line therapy during TH. The primary measure in this initiative was cumulative opioid exposure during TH; balancing measures included safety parameters, primarily the rate of dexmedetomidine discontinuation because of bradycardia. Baseline demographic and clinical data were collected retrospectively for the period before implementation and prospectively during the QI peri

SUBMITTER: Elliott M 

PROVIDER: S-EPMC10750168 | biostudies-literature | 2024 Jan

REPOSITORIES: biostudies-literature