Inducible caspase 9-mediated suicide gene therapy using AAV6 vectors in a murine model of breast cancer.

ABSTRACT: Breast carcinoma has one of the highest incidence rates (11.7%), with significant clinical heterogeneity. Although conventional chemotherapy and surgical resection are the current standard of care, the resistance and recurrence, after these interventions, necessitate alternate therapeutic approaches. Cancer gene therapy for breast cancer with the suicide gene is an attractive option due to their directed delivery into the tumor. In this study, we have developed a novel treatment strategy against breast cancer with recombinant adeno-associated virus (AAV) serotype 6 vectors carrying a suicide gene, inducible Caspase 9 (iCasp9). Upon treatment with AAV6-iCasp9 vectors and the chemical inducer of dimerizer, AP20187, the viability of murine breast cancer cells (4T1) was si

SUBMITTER: Pathak S 

PROVIDER: S-EPMC10750187 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature