Rebalancing TGF-β/PGE₂ breaks RT-induced immunosuppressive barriers by enhancing tumor-infiltrated dendritic cell homing.

ABSTRACT: A better understanding of how tumor microenvironments shape immune responses after radiotherapy (RT) is required to improve patient outcomes. This study focuses on the observation that dendritic cells (DCs) infiltrating irradiated cervical tumors are retained in transforming growth factor (TGF)-β-abundant regions. We report that TGF-β secretion from cervical cancer cells was increased by irradiation in a dose-dependent manner and that this significantly suppressed the expression of allostimulatory markers and Th1 cytokines in DCs. To investigate further, we blocked the TGF-β signal in DCs and observed that RT had a dose-dependent immune-promoting effect, improving DC maturation. This suggested that proinflammatory mediators may also be induced by RT, but their effects were being counteract

SUBMITTER: Zhou Z 

PROVIDER: S-EPMC10750293 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature