Clinical parameter-guided initial resuscitation in adult patients with septic shock: A systematic review and network meta-analysis.

ABSTRACT:

Aim

To identify the most useful tissue perfusion parameter for initial resuscitation in sepsis/septic shock adults using a network meta-analysis.

Methods

We searched major databases until December 2022 for randomized trials comparing four tissue perfusion parameters or against usual care. The primary outcome was short-term mortality up to 90 days. The Confidence in Network Meta-Analysis web application was used to assess the quality of evidence.

Results

Seventeen trials were identified. Lactate-guided therapy (risk ratios, 0.59; 95% confidence intervals [0.45-0.76]; high certainty) and capillary refill time-guided therapy (risk ratios, 0.53; 95% confidence intervals [0.33-0.86]; high certainty) were significantly associated with lower short-term mortality compared wit

SUBMITTER: Yumoto T 

PROVIDER: S-EPMC10750303 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature