Far-red BODIPY-based oxime esters: photo-uncaging and drug delivery.

ABSTRACT: Far-red BODIPY-based oxime esters for photo-uncaging were designed to release molecules of interest with carboxylic acids. The low power red LED light breaks the N-O oxime ester bond and frees the caged molecules. We studied the mechanism and kinetics of the uncaging procedure using a ¹H NMR spectrometer. Moreover, the drug delivery strategy to release valproic acid (VPA) on demand was tested in vitro using this far-red BODIPY photo-uncaging strategy to induce apoptosis in tumor cells.

SUBMITTER: Wan Z 

PROVIDER: S-EPMC10750304 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature