MiR-758-3p/ILK signaling modulated angiogenesis by regulating VEGFA in wound healing.

ABSTRACT: Chronic wounds cause physical, psychological and economic damage to patients, while therapeutic choices are limited. ILK was reported to play key roles in both fibrosis and angiogenesis, which are two important factors during wound healing. However, the function of ILK during vascularization in wounds remains unclear. In our study, we found increased ILK expression in chronic wound tissues compared to adjacent tissue, as well as a positive relationship between ILK expression and microvessel density. Moreover, fibroblasts overexpressing ILK showed an enhanced ability to promote HUVEC migration and tube formation, during which PI3K/Akt, downstream of ILK, played key roles and VEGFA was the key cytokine. Considering the important function of ILK in wound healing and the lack of an ILK activat

SUBMITTER: Wang R 

PROVIDER: S-EPMC10750343 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature