Circulating levels of cytokines and risk of inflammatory bowel disease: evidence from genetic data.

ABSTRACT:

Background

Prior epidemiological studies have established a correlation between inflammatory cytokines and inflammatory bowel disease (IBD). However, the nature of this relationship remains uncertain. Mendelian randomization (MR) study has the advantages of avoiding confounding and reverse causality compared with traditional observational research.

Objective

We aimed to evaluate whether genetically determined circulating levels of cytokines are associated with the risk of IBD by using the MR approach.

Materials and methods

We selected genetic variants associated with circulating levels of 28 cytokines at the genome-wide significance level from a genome-wide association study (GWAS) including 8,293 individuals. Summary-level data for IBD (including Crohn's disease and

SUBMITTER: Liu B 

PROVIDER: S-EPMC10750389 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature