The KIR repertoire of a West African chimpanzee population is characterized by limited gene, allele, and haplotype variation.

ABSTRACT:

Introduction

The killer cell immunoglobulin-like receptors (KIR) play a pivotal role in modulating the NK cell responses, for instance, through interaction with major histocompatibility complex (MHC) class I molecules. Both gene systems map to different chromosomes but co-evolved during evolution. The human KIR gene family is characterized by abundant allelic polymorphism and copy number variation. In contrast, our knowledge of the KIR repertoire in chimpanzees is limited to 39 reported alleles, with no available population data. Only three genomic KIR region configurations have been mapped, and seventeen additional ones were deduced by genotyping.

Methods

Previously, we documented that the chimpanzee MHC class I repertoire has been skewed due to an anci

SUBMITTER: de Groot NG 

PROVIDER: S-EPMC10750417 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature