Sensitivity Analysis of Upper Limb Musculoskeletal Models During Isometric and Isokinetic Tasks.

ABSTRACT: Sensitivity coefficients are used to understand how errors in subject-specific musculoskeletal model parameters influence model predictions. Previous sensitivity studies in the lower limb calculated sensitivity using perturbations that do not fully represent the diversity of the population. Hence, the present study performs sensitivity analysis in the upper limb using a large synthetic dataset to capture greater physiological diversity. The large dataset (n = 401 synthetic subjects) was created by adjusting maximum isometric force, optimal fiber length, pennation angle, and bone mass to induce atrophy, hypertrophy, osteoporosis, and osteopetrosis in two upper limb musculoskeletal models. Simulations of three isometric and two isokinetic upper limb tasks were performed using each synthetic

SUBMITTER: Diaz MT 

PROVIDER: S-EPMC10750789 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature