Changes in tissue sodium concentration and sodium relaxation times during the maturation of human knee cartilage: Ex vivo ²³ Na MRI study at 10.5 T.

ABSTRACT:

Purpose

To evaluate the influence of skeletal maturation on sodium (²³ Na) MRI relaxation parameters and the accuracy of tissue sodium concentration (TSC) quantification in human knee cartilage.

Methods

Twelve pediatric knee specimens were imaged with whole-body 10.5 T MRI using a density-adapted 3D radial projection sequence to evaluate ²³ Na parameters: B₁ ⁺ , T₁ , biexponential T 2 * $$ {\mathrm{T}}_2^{\ast } $$ , and TSC. Water, collagen, and sulfated glycosaminoglycan (sGAG) content were calculated from osteochondral biopsies. The TSC was corrected for B₁ ⁺ , relaxation, and water content. The literature-based TSC (TSC_LB ) used previously published values for corrections, whereas

SUBMITTER: Zbyn S 

PROVIDER: S-EPMC10751033 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature