BMI and Cardiometabolic Traits in Japanese: A Mendelian Randomization Study.

ABSTRACT:

Background

Although many observational studies have demonstrated significant relationships between obesity and cardiometabolic traits, the causality of these relationships in East Asians remains to be elucidated.

Methods

We conducted individual-level Mendelian randomization (MR) analyses targeting 14,083 participants in the Japan Multi-Institutional Collaborative Cohort Study and two-sample MR analyses using summary statistics based on genome-wide association study data from 173,430 Japanese. Using 83 body mass index (BMI)-related loci, genetic risk scores (GRS) for BMI were calculated, and the effects of BMI on cardiometabolic traits were examined for individual-level MR analyses using the two-stage least squares estimator method. The β-coefficients and standard errors for

SUBMITTER: Nagayoshi M 

PROVIDER: S-EPMC10751192 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature