Sweat gland nerve fiber density and association with sudomotor function, symptoms, and risk factors in adolescents with type 1 diabetes.

ABSTRACT:

Purpose

To quantify sweat gland nerve fiber density in adolescents with diabetes. Additionally, to investigate associations between sudomotor innervation, sweat responses, and possible risk factors for sudomotor neuropathy.

Methods

Cross-sectional study where 60 adolescents with type 1 diabetes (duration > 5 years) and 23 control subjects were included. Clinical data, quantitative sudomotor axon reflex test, and skin biopsies were obtained. Skin tissue was immunostained and imaged by confocal microscopy. Quantification of the sweat gland volume and three-dimensional reconstruction of the nerve fibers was performed using a design-unbiased technique.

Results

Adolescents with diabetes had a significant reduction of maximum and mean values of nerve fiber length and nerve

SUBMITTER: Rasmussen VF 

PROVIDER: S-EPMC10751258 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature