Unique characteristics of the tumor immune microenvironment in young patients with metastatic colorectal cancer.

ABSTRACT:

Introduction

Metastatic colorectal cancer (mCRC) remains a common and highly morbid disease, with a recent increase in incidence in patients younger than 50 years. There is an acute need to better understand differences in tumor biology, molecular characteristics, and other age-related differences in the tumor microenvironment (TME).

Methods

111 patients undergoing curative-intent resection of colorectal liver metastases were stratified by age into those <50 years or >65 years old, and tumors were subjected to multiplex fluorescent immunohistochemistry (mfIHC) to characterize immune infiltration and cellular engagement.

Results

There was no difference in infiltration or proportion of immune cells based upon age, but the younger cohort had a higher proportion of progra

SUBMITTER: Griffith BD 

PROVIDER: S-EPMC10751347 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature