Cortical thickness moderates intraindividual variability in prefrontal cortex activation patterns of older adults during walking.

ABSTRACT:

Objective

Increased intraindividual variability (IIV) in behavioral and cognitive performance is a risk factor for adverse outcomes but research concerning hemodynamic signal IIV is limited. Cortical thinning occurs during aging and is associated with cognitive decline. Dual-task walking (DTW) performance in older adults has been related to cognition and neural integrity. We examined the hypothesis that reduced cortical thickness would be associated with greater increases in IIV in prefrontal cortex oxygenated hemoglobin (HbO₂) from single tasks to DTW in healthy older adults while adjusting for behavioral performance.

Method

Participants were 55 healthy community-dwelling older adults (mean age = 74.84, standard deviation (SD) = 4.97). Structural MRI was u

SUBMITTER: Ross D 

PROVIDER: S-EPMC10751394 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature