Mammalian target of rapamycin inhibition impacts energy homeostasis and induces sex-specific body weight loss in humans.

ABSTRACT:

Background

Previous data from a 2-year randomized controlled trial (CRAD001ADE12) indicated that mammalian target of rapamycin (mTOR) inhibition by everolimus slowed cyst growth in patients with autosomal-dominant polycystic kidney disease (ADPKD). During the trial, we noted body weight loss in some patients, particularly in women. We hypothesized that everolimus causes body weight reduction by reduced food intake and/or metabolic changes, which could lead to cachexia.

Methods

Within a sub-analysis of the CRAD001ADE12 trial, body weight course was investigated regarding sex-specific differences in 433 adult ADPKD patients (everolimus, n = 215; placebo, n = 218). One hundred four out of 111 patients who participated in the clinical trial centre in Berlin were evaluated under

SUBMITTER: Mannaa M 

PROVIDER: S-EPMC10751400 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature