Altered gut microbiome, bile acid composition and metabolome in sarcopenia in liver cirrhosis.

ABSTRACT:

Background

Sarcopenia in liver cirrhosis is associated with low quality of life and high mortality risk. The pathogenesis has yet to be fully understood. We hypothesized that gut microbiome, bile acid (BA) composition and metabolites differ between cirrhotic patients with and without sarcopenia and contribute to pathogenesis.

Methods

Cirrhotic patients with (n = 78) and without (n = 38) sarcopenia and non-cirrhotic controls with (n = 39) and without (n = 20) sarcopenia were included in this study. Faecal microbiome composition was studied by 16S rDNA sequencing, serum and faecal BA composition by ultra-high-performance liquid chromatography-tandem mass spectrometry, and metabolite composition in serum, faeces and urine by nuclear magnetic resonance.

Results

Bacteroide

SUBMITTER: Aliwa B 

PROVIDER: S-EPMC10751428 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature